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STAT6 anticorps (C-Term) (PE)

STAT6 Reactivité: Humain, Souris, Rat, Boeuf (Vache) ICS Hôte: Souris Monoclonal 23-Stat6 PE
N° du produit ABIN1176939
  • Antigène Voir toutes STAT6 Anticorps
    STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
    Épitope
    • 37
    • 16
    • 13
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 132
    • 78
    • 62
    • 10
    • 10
    • 8
    • 7
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache)
    Hôte
    • 105
    • 30
    • 4
    • 1
    Souris
    Clonalité
    • 101
    • 38
    Monoclonal
    Conjugué
    • 78
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp STAT6 est conjugé à/à la PE
    Application
    • 70
    • 44
    • 43
    • 27
    • 26
    • 24
    • 19
    • 18
    • 16
    • 9
    • 8
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Intracellular Staining (ICS)
    Marque
    BD Phosflow™
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Stat6 C-terminal Recombinant Protein
    Clone
    23-Stat6
    Isotype
    IgG1
    Top Product
    Discover our top product STAT6 Anticorps primaire
  • Volume d'échantillon
    20 μL
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Heim: "The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus." dans: European journal of clinical investigation, Vol. 26, Issue 1, pp. 1-12, (1996) (PubMed).

  • Antigène
    STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
    Autre désignation
    Stat6 (STAT6 Produits)
    Synonymes
    anticorps D12S1644, anticorps IL-4-STAT, anticorps STAT6B, anticorps STAT6C, anticorps signal transducer and activator of transcription 6, anticorps signal transducer and activator of transcription 6-like, anticorps STAT6, anticorps Stat6, anticorps LOC100859543
    Sujet
    STATs (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including Interleukins (IL) 2-5, IL-7, IL-15, GM-CSF, erythropoietin and growth hormone. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of STATs by tyrosine phosphorylation. Active STATs then move to the nucleus to promote transcription of cytokine-inducible genes. Seven STAT proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat6 plays an important role in signaling pathways that lead to the differentiation of T helper type 2 (Th2) cells from uncommitted CD4 T cell precursors. Moreover, IL-4, secreted by activated T lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. The 23/Stat6 monoclonal antibody recognizes Stat6, regardless of phosphorylation status.
    Pathways
    Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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