Prostaglandin D2 Receptor 2 (PTGDR2) anticorps

N° du produit ABIN122155

Détail du produit

Antigène: Prostaglandin D2 Receptor 2 (PTGDR2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: Reacts with G Protein-Coupled Receptor GPR44 (CRTH2, family: GPCR, subfamily: Prostanoid).

Purification: Peptide immunogen affinity column.

Immunogène: Synthetic peptide - KLH conjugated

Information d'application

Indications d'application: Immunocytochemistry. Immunohistochemistry with formalin fixed paraffin embedded tissues: 3-6 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS containing 0.01 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détail du antigène

Antigène: Prostaglandin D2 Receptor 2 (PTGDR2)

Autre désignation: CD294 / GPR44 (PTGDR2 Produits)

Synonymes: anticorps CD294, anticorps CRTH2, anticorps DL1R, anticorps DP2, anticorps GPR44, anticorps Crth2, anticorps Grp45, anticorps Ptgdr2, anticorps Gpr44, anticorps prostaglandin D2 receptor 2, anticorps PTGDR2, anticorps Ptgdr2

Sujet: GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells. CRTH2 has been reported to be expressed in the central nervous system, peripheral tissues, and in blood cells, particularly activated T helper-2 cells. Two transcripts have been isolated, a 3.5-kb transcript expressed primarily in the thalamus, frontal cortex, pons, and hippocampus, and a 3.4-kb transcript expressed in fetal liver, leukocytes, and thymus. ESTs have been isolated from B-cell/lung/testis, brain, kidney, liver/spleen, placenta, prostate, testis, and thymus libraries.Synonyms: CRTH2, Chemoattractant receptor-homologous molecule expressed on Th2 cells, DL1R, Putative G-protein coupled receptor 44

ID gène: 11251

UniProt: Q9Y5Y4

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling