MDM4-binding Protein anticorps (pSer367)

N° du produit ABIN1449256

Détail du produit anti-MDM4-binding Protein anticorps

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Épitope: pSer367

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MDM4-binding Protein est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody specifically recognizes MdmX protein phosphorylated at Ser367.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse

Clone: #15

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur MDM4-binding Protein

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Autre désignation: MDM4 (MDM4 Produits)

Synonymes: anticorps mdmx, anticorps HDMX, anticorps MDMX, anticorps MRP1, anticorps wu:fa09h09, anticorps wu:fi33d10, anticorps 4933417N07Rik, anticorps AA414968, anticorps AL023055, anticorps AU018793, anticorps AU021806, anticorps C85810, anticorps Mdmx, anticorps MDM4, p53 regulator S homeolog, anticorps MDM4, p53 regulator, anticorps transformed mouse 3T3 cell double minute 4, anticorps mdm4.S, anticorps MDM4, anticorps Mdm4, anticorps mdm4

Sujet: MdmX (Mdm4, HdmX) inhibits p53-and p73-dependent cell cycle arrest and apoptosis by binding to the transcription activation domains of these proteins. MdmX consists of 490 amino acids with the molecular weight of 54,864 and contains a RIING-finger domain and a nuclear transport signal. It is known that the protein migrates aberrantly in SDS-PAGE at the position of an 80 kDa protein. MdmX is phosphorylated at Ser367 by Chk2 kinase downstream of ATM in response to DNA damage, and as the result, it binds to 14-3-3 and is transported into nucleus where it is degraded by Mdm2. This process activates the p53 functions (Ref 1, 2, 3).Synonyms: Double minute 4 protein, MDM-4, MDMX, Mdm2-like p53-binding protein, p53-binding protein Mdm4

ID gène: 4194

NCBI Accession: NP_002384

UniProt: O15151

Pathways: Cycle Cellulaire