SNCA anticorps

N° du produit ABIN361093

Détail du produit anti-SNCA anticorps

Antigène: SNCA (Synuclein, alpha (SNCA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SNCA est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography

Immunogène: Recombinant human alpha-synuclein (61-95) purified from E. coli. NCBI Accession No.: NP_000336.

Clone: 5C2

Isotype: IgG1

Information d'application

Indications d'application: The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:2,000. This antibody (5C2) has the specificity against the NAC domain (61-95aa) of alpha-synuclein. Recommended starting dilution is 1:1,000.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml

Buffer: Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur SNCA

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: A-Synuclein (SNCA Produits)

Synonymes: anticorps snca, anticorps MGC64356, anticorps LOC619283, anticorps NACP, anticorps alphaSYN, anticorps PARK1, anticorps PARK4, anticorps PD1, anticorps synuclein alpha L homeolog, anticorps alpha-synuclein, anticorps synuclein alpha, anticorps synuclein, alpha, anticorps snca.L, anticorps LOC619283, anticorps SNCA, anticorps Snca

Sujet: Alpha-synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-Abeta component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain. Clone: Anti-human alpha-Synuclein mAb, clone 5C2, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein. This antibody specifically recognizes alpha-synuclein only, particularly the NAC domain of alpha-synuclein.

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity