ERCC8 anticorps (AA 161-260) (Alexa Fluor 488)
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- Antigène Voir toutes ERCC8 Anticorps
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
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Épitope
- AA 161-260
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ERCC8 est conjugé à/à la Alexa Fluor 488
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Horse
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human ERCC8/CSA
- Isotype
- IgG
- Top Product
- Discover our top product ERCC8 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
- Autre désignation
- ERCC8/CSA (ERCC8 Produits)
- Synonymes
- anticorps zgc:103550, anticorps CKN1, anticorps CSA, anticorps UVSS2, anticorps Ckn1, anticorps 2410022P04Rik, anticorps 2810431L23Rik, anticorps 4631412O06Rik, anticorps B130065P18Rik, anticorps Csa, anticorps excision repair cross-complementation group 8, anticorps ERCC excision repair 8, CSA ubiquitin ligase complex subunit, anticorps excision repaiross-complementing rodent repair deficiency, complementation group 8, anticorps ercc8, anticorps ERCC8, anticorps Ercc8
- Sujet
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Synonyms: CSA, CKN1, UVSS2, DNA excision repair protein ERCC-8, Cockayne syndrome WD repeat protein CSA, ERCC8
Background: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner, ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
- ID gène
- 1161
- UniProt
- Q13216
- Pathways
- Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
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