VAV1 anticorps (AA 121-324)
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- Antigène Voir toutes VAV1 Anticorps
- VAV1 (Vav 1 Oncogene (VAV1))
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Épitope
- AA 121-324
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp VAV1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.
- Isotype
- IgG1
- Top Product
- Discover our top product VAV1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/mL
- Buffer
- PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
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- Antigène
- VAV1 (Vav 1 Oncogene (VAV1))
- Autre désignation
- VAV1 (VAV1 Produits)
- Synonymes
- anticorps VAV, anticorps Vav, anticorps vav-T, anticorps vav guanine nucleotide exchange factor 1, anticorps vav 1 oncogene, anticorps vav guanine nucleotide exchange factor 1 L homeolog, anticorps VAV1, anticorps Vav1, anticorps vav1.L
- Sujet
- The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
- Poids moléculaire
- 98.3 kDa
- ID gène
- 7409
- UniProt
- P15498
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling
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