HIF1A anticorps (C-Term)

N° du produit ABIN1881413

Détail du produit anti-HIF1A anticorps

Antigène: HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Épitope: AA 735-762, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIF1A est non-conjugé

Application: Western Blotting (WB)

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HIF1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-762 amino acids from the C-terminal region of human HIF1A.

Clone: RB41484

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-HIF1A (ABIN1881413)

Espinosa, José Carnicer, Catasus, Canet, Dangelo, Zannoni, Prat: "Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role." dans: The American journal of surgical pathology, Vol. 34, Issue 11, pp. 1708-14, (2010) (PubMed).

Corzo, Condamine, Lu, Cotter, Youn, Cheng, Cho, Celis, Quiceno, Padhya, McCaffrey, McCaffrey, Gabrilovich: "HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment." dans: The Journal of experimental medicine, Vol. 207, Issue 11, pp. 2439-53, (2010) (PubMed).

Shen, Zhang, Liu, Zhang: "Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia." dans: FEBS letters, Vol. 584, Issue 20, pp. 4366-72, (2010) (PubMed).

Gonsalves, Kalra: "Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6253-64, (2010) (PubMed).

Hindryckx, De Vos, Jacques, Ferdinande, Peeters, Olievier, Bogaert, Brinkman, Vandenabeele, Elewaut, Laukens: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, (2010) (PubMed).

Détails sur HIF1A

Antigène: HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Autre désignation: HIF1A (HIF1A Produits)

Synonymes: anticorps hif1a, anticorps AA959795, anticorps HIF1alpha, anticorps MOP1, anticorps bHLHe78, anticorps HIF-1A, anticorps HIF-1alpha, anticorps HIF1, anticorps HIF1-ALPHA, anticorps PASD8, anticorps HIF1-alpha, anticorps hif-1a, anticorps hypoxia inducible factor 1 alpha, anticorps hypoxia inducible factor 1, alpha subunit, anticorps hypoxia inducible factor 1 alpha subunit, anticorps HIF (Hypoxia Inducible Factor) homologa, anticorps hif-1a, anticorps Hif1a, anticorps HIF1A, anticorps hif1a, anticorps hif-1

Sujet: Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.

Poids moléculaire: 92670

NCBI Accession: NP_001230013, NP_001521, NP_851397

UniProt: Q16665

Pathways: Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, L'effet Warburg