IRAK1 anticorps (AA 618-712)

N° du produit ABIN1885516

Détail du produit anti-IRAK1 anticorps

Antigène: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Épitope: AA 618-712

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IRAK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunoaffinity chromotography purified IgG

Immunogène: Raised against a recombinant protein corresponding to amino acids 618 - 712 of human IRAK.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: -20 °C

Stockage commentaire: Can be stored at -20 °C, stable for one year.

Date de péremption: 12 months

Détails sur IRAK1

Antigène: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Autre désignation: IRAK (IRAK1 Produits)

Synonymes: anticorps IRAK1, anticorps IRAK, anticorps pelle, anticorps AA408924, anticorps IRAK-1, anticorps IRAK1-S, anticorps Il1rak, anticorps Plpk, anticorps mPLK, anticorps RGD1563841, anticorps interleukin 1 receptor associated kinase 1, anticorps interleukin-1 receptor-associated kinase 1, anticorps IRAK1, anticorps irak1, anticorps Irak1

Sujet: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses.NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS.A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently.IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response.IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Synonyms: IRAK (8F1A7),IL-1-Receptor Associated Kinase

Pathways: Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades