anticorps RT1.Ma, anticorps RT1.DMa, anticorps HLA-DMA, anticorps H-2Ma, anticorps H2-Ma, anticorps D6S222E, anticorps DMA, anticorps HLADM, anticorps RING6, anticorps RT1 class II, locus DMa, anticorps SLA-DM alpha chain, anticorps major histocompatibility complex, class II, DM alpha, anticorps histocompatibility 2, class II, locus DMa, anticorps RT1-DMa, anticorps SLA-DMA, anticorps DLA-DMA, anticorps H2-DMa, anticorps HLA-DMA
Sujet
HLA-DMA belongs to the HLA class II alpha chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane.It is located in intracellular vesicles.DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The alpha chain is approximately 33-35 kDa and its gene contains 5 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.[provided by RefSeq]