TANK anticorps (C-Term)

N° du produit ABIN1886965

Détail du produit anti-TANK anticorps

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TANK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 14 amino acid peptide from near the carboxy terminus of human TANK.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur TANK

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Autre désignation: TANK (TANK Produits)

Synonymes: anticorps I-TRAF, anticorps ITRAF, anticorps TRAF2, anticorps C86182, anticorps E430026L09Rik, anticorps zgc:153048, anticorps i-traf, anticorps tank, anticorps traf2, anticorps TRAF family member associated NFKB activator, anticorps TRAF family member-associated Nf-kappa B activator, anticorps TRAF family member-associated NFKB activator, anticorps TRAF family member associated NFKB activator L homeolog, anticorps TANK, anticorps Tank, anticorps tank, anticorps tank.L

Sujet: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction.Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB.This activation of NF-kappaB occurs through an association with the kinases IKKepsilon and TBK1.More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkappaB complex.This suggests that in addition to the possibility that TBK1 and IKKepsilon activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappaB proteins.At least two isoforms of TANK are known to exist.
Synonyms: TRAF family member-associated NF-kappaB activator, I-TRAF

NCBI Accession: NP_004171

Pathways: Signalisation p53, Signalisation TLR, Activation of Innate immune Response