ALKBH2 anticorps (C-Term)

N° du produit ABIN1887037

Détail du produit anti-ALKBH2 anticorps

Antigène: ALKBH2 (AlkB, Alkylation Repair Homolog 2 (ALKBH2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALKBH2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide near the carboxy terminus of human ALKBH2.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur ALKBH2

Antigène: ALKBH2 (AlkB, Alkylation Repair Homolog 2 (ALKBH2))

Autre désignation: ALKBH2 (ALKBH2 Produits)

Synonymes: anticorps si:dkey-65b12.2, anticorps ABH2, anticorps 9530023G02, anticorps AU016977, anticorps Abh2, anticorps mABH2, anticorps RGD1306377, anticorps alkB homolog 2, alpha-ketoglutarate dependent dioxygenase, anticorps alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase, anticorps ALKBH2, anticorps alkbh2, anticorps Alkbh2

Sujet: The E.coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA, ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells.Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation.Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer.Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
Synonyms: Alpha-ketoglutarate-dependent dioxygenase alkB homolog2, alkylation repair homolog 2, ABH2

NCBI Accession: NP_001138847

Pathways: Réparation de l'ADN