PAK4 anticorps (Center)

N° du produit ABIN1887484

Détail du produit anti-PAK4 anticorps

Antigène: PAK4 (P21-Activated Kinase 4 (PAK4))

Épitope: Center

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAK4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide from near the center of human PAK4.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur PAK4

Antigène: PAK4 (P21-Activated Kinase 4 (PAK4))

Autre désignation: PAK4 (PAK4 Produits)

Synonymes: anticorps 5730488L07Rik, anticorps AW555722, anticorps mKIAA1142, anticorps im:5916170, anticorps wu:fd12b01, anticorps zgc:92014, anticorps p21 (RAC1) activated kinase 4, anticorps p21 protein (Cdc42/Rac)-activated kinase 4, anticorps PAK4, anticorps Pak4, anticorps pak4

Sujet: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac.They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding.Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding.The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility.Much less is known about the second group, which includes PAK4, 5 and 6.These proteins are not activated by Cdc42/Rac binding.PAK4 was initially identified as a novel effector of Cdc42Hs.Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization.Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development.PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
Synonyms: p21-activated kinase 4

NCBI Accession: NP_005875

Pathways: Signalisation RTK