FAM33A anticorps (N-Term)

N° du produit ABIN1887913

Détail du produit anti-FAM33A anticorps

Antigène: FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM33A est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide from near the amino terminus of human SKA2.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur FAM33A

Antigène: FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))

Autre désignation: SKA2 (FAM33A Produits)

Synonymes: anticorps FAM33A, anticorps 1110001A07Rik, anticorps C78640, anticorps Fam33a, anticorps RGD1307084, anticorps fam33a, anticorps spindle and kinetochore associated complex subunit 2, anticorps Spindle and kinetochore-associated protein 2, anticorps SKA2, anticorps Ska2, anticorps ska2

Sujet: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes.Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs.A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset.Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure.Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.
Synonyms: Spindle and kinetochore associated complex subunit 2, FAM33A

NCBI Accession: NP_872426

Pathways: M Phase