Leptin Receptor anticorps

N° du produit ABIN2192046

Détail du produit anti-Leptin Receptor anticorps

Antigène: Leptin Receptor (LEPR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Leptin Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Stérilité: 0.2 μm filtered

Clone: 2F1

Information d'application

Indications d'application: For Western blot, immuno assays and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-Leptin Receptor (ABIN2192046)

van Dielen, van t Veer, Buurman, Greve: "Leptin and soluble leptin receptor levels in obese and weight-losing individuals." dans: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 4, pp. 1708-16, (2002) (PubMed).

Détails sur Leptin Receptor

Antigène: Leptin Receptor (LEPR)

Abstract: LEPR Produits

Synonymes: anticorps CD295, anticorps LEP-R, anticorps LEPRD, anticorps OB-R, anticorps OBR, anticorps obr, anticorps cd295, anticorps ob-rb, anticorps Fa, anticorps LEPROT, anticorps Leprb, anticorps Modb1, anticorps OB-RGRP, anticorps Obr, anticorps db, anticorps diabetes, anticorps obese-like, anticorps obl, anticorps ObRb, anticorps Ob-R, anticorps Ob-RM, anticorps lepr, anticorps leptin receptor, anticorps leptin receptor S homeolog, anticorps LEPR, anticorps lepr, anticorps Lepr, anticorps lepr.S

Sujet: The monoclonal antibody 2F1 reacts with human soluble leptin receptor (sLR) in plasma. Leptin is a cytokine that is primarily expressed by adipose tissue. Leptin controls food intake by its interaction with the leptin receptor in the brain. Leptin action is mediated and controlled by the leptin receptor, a class I type cytokine receptor. sLR is generated by proteolytic cleavage of membrane-anchored receptors. This indicates that the leptin receptor might have other functions besides transduction. Binding of leptin with sLR increases the bioavailability of leptin in plasma, but also decreases the binding of leptin to membrane bound leptin receptors. For example, when comparing obese and lean individuals, plasma levels of sLR are significantly decreased whereas leptin levels are significantly increased. The monoclonal antibody 2F1 specifically reacts with sLR with a molecular mass of 180kD. The 2F1 antibody can be used to measure in both free sLR and sLR bound to leptin in plasma.

Pathways: Signalistation JAK/STAT, AMPK Signaling, Feeding Behaviour