NFKBIB anticorps
-
- Antigène Voir toutes NFKBIB Anticorps
- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
-
Reactivité
- Humain, Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp NFKBIB est non-conjugé
-
Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by peptide affinity chromatography method.
- Immunogène
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NFKBIB.
- Top Product
- Discover our top product NFKBIB Anticorps primaire
-
-
- Indications d'application
- NFKBIB antibody can be used for detection of NFKBIB by ELISA at 1:2500. NFKBIB antibody can be used for detection of NFKBIB by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Conseil sur la manipulation
- As with any antibody avoid repeat freeze-thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store NFKBIB antibody at -20 °C.
-
- Antigène
- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
- Autre désignation
- NFKBIB (NFKBIB Produits)
- Synonymes
- anticorps NFKBIB, anticorps IKB-beta, anticorps IKappaBbeta, anticorps IkB, anticorps IkBb, anticorps IKBB, anticorps TRIP9, anticorps NFKB inhibitor beta, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta, anticorps NFKBIB, anticorps Nfkbib
- Sujet
- NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
- Poids moléculaire
- 38 kDa
- ID gène
- 4793
- NCBI Accession
- NP_002494
- UniProt
- Q15653
- Pathways
- Signalisation NF-kappaB, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
-