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CD28 anticorps

CD28 Reactivité: Humain FACS, IP, Func, IHC Hôte: Souris Monoclonal CD28-2 unconjugated
N° du produit ABIN2567423
  • Antigène Voir toutes CD28 Anticorps
    CD28
    Reactivité
    • 181
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    Humain
    Hôte
    • 143
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    • 28
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    Souris
    Clonalité
    • 200
    • 74
    • 3
    Monoclonal
    Conjugué
    • 93
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    Cet anticorp CD28 est non-conjugé
    Application
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func), Immunohistochemistry (IHC)
    Specificité
    The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes.
    Purification
    The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.
    Clone
    CD28-2
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD28 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2 mg/mL
    Buffer
    Phosphate-buffered aqueous solution, ph7.2.
    Stock
    4 °C
    Stockage commentaire
    The product should be stored undiluted at 4°C. Do not freeze.
  • Antigène
    CD28
    Autre désignation
    CD28 (CD28 Produits)
    Synonymes
    anticorps Tp44, anticorps CD28RNA, anticorps cd28, anticorps CD28 molecule, anticorps CD28 antigen, anticorps Cd28 molecule, anticorps CD28 molecule L homeolog, anticorps CD28, anticorps Cd28, anticorps cd28.L
    Sujet
    The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 Molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
    ID gène
    920
    UniProt
    P10747
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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