FADD anticorps (pSer191)

N° du produit ABIN2568129

Détail du produit anti-FADD anticorps

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Épitope: pSer191

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FADD est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: The antibody detects endogenous levels of FADD only when phosphorylated at serine 191.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: FADD (phospho Ser191) antibody was raised against a peptide sequence around phosphorylation site of Serine191 (R-S-G (p)-A-M) derived from Human FADD.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur FADD

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Autre désignation: FADD (FADD Produits)

Synonymes: anticorps MORT1, anticorps Mort1/FADD, anticorps Mort1, anticorps TNFRSF6, anticorps adaptor, anticorps fadd, anticorps mort1, anticorps xfadd, anticorps Fas associated via death domain, anticorps Fas (TNFRSF6)-associated via death domain, anticorps Fas associated via death domain S homeolog, anticorps Fas (tnfrsf6)-associated via death domain, anticorps FADD, anticorps Fadd, anticorps fadd.S, anticorps fadd

Sujet: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Poids moléculaire: 25 kDa

ID gène: 14082

NCBI Accession: NP_003815

UniProt: Q13158

Pathways: Apoptose, Signalisation TLR, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades