PRKAB1 anticorps (AA 2-100) (Alexa Fluor 647)

N° du produit ABIN2690022

Détail du produit anti-PRKAB1 anticorps (Alexa Fluor 647)

Antigène: PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))

Épitope: AA 2-100

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAB1 est conjugé à/à la Alexa Fluor 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Rat

Homologie: Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human AMPK beta 1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PRKAB1

Antigène: PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))

Autre désignation: AMPK beta 1 (PRKAB1 Produits)

Synonymes: anticorps AMPK, anticorps HAMPKb, anticorps 1300015D22Rik, anticorps AU021155, anticorps E430008F22, anticorps MGC82489, anticorps prkab1, anticorps wu:fk93d05, anticorps wu:fw87e09, anticorps zgc:56652, anticorps zgc:76975, anticorps zgc:92228, anticorps protein kinase AMP-activated non-catalytic subunit beta 1, anticorps protein kinase, AMP-activated, beta 1 non-catalytic subunit, anticorps protein kinase, AMP-activated, beta 1 non-catalytic subunit S homeolog, anticorps protein kinase, AMP-activated, beta 1 non-catalytic subunit, b, anticorps protein kinase, AMP-activated, beta 1 non-catalytic subunit, a, anticorps PRKAB1, anticorps Prkab1, anticorps prkab1.S, anticorps prkab1, anticorps prkab1b, anticorps prkab1a

Sujet:

Synonyms: AMPK, HAMPKb, 5'-AMP-activated protein kinase subunit beta-1, AMPK subunit beta-1, AMPKb, PRKAB1

Background: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

ID gène: 5564

UniProt: Q9Y478

Pathways: AMPK Signaling, L'effet Warburg