STAT2 anticorps

N° du produit ABIN271825

Détail du produit anti-STAT2 anticorps

Antigène: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAT2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of STAT2 protein. (region surrounding Leu684)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur STAT2

Antigène: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Autre désignation: STAT2 (STAT2 Produits)

Synonymes: anticorps wu:fj84d07, anticorps p113, anticorps stat2, anticorps 1600010G07Rik, anticorps AW496480, anticorps ISGF-3, anticorps P113, anticorps STAT113, anticorps signal transducer and activator of transcription 2, anticorps AGAP000099-PA, anticorps stat2, anticorps STAT2, anticorps Stat2

Sujet: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.Synonyms: Signal transducer and activator of transcription 2, p113

Poids moléculaire: approx. 113 kDa

ID gène: 6773

NCBI Accession: NP_005410

UniProt: P52630

Pathways: Signalistation JAK/STAT, Hepatitis C, CXCR4-mediated Signaling Events