Glucocorticoid Receptor anticorps (N-Term)

N° du produit ABIN784709

Détail du produit anti-Glucocorticoid Receptor anticorps

Antigène: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Mouton, Porc, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glucocorticoid Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV

Homologie: Cow: 79%, Horse: 79%, Human: 100%, Mouse: 79%, Pig: 79%, Rabbit: 86%, Rat: 86%, Sheep: 79%

Attributs du produit: This is a rabbit polyclonal antibody against NR3C1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NR3C1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 777 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Glucocorticoid Receptor

Antigène: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Autre désignation: NR3C1 (NR3C1 Produits)

Synonymes: anticorps GR, anticorps gcr, anticorps grl, anticorps xGR, anticorps gccr, anticorps gr, anticorps zgc:113038, anticorps NR3C1, anticorps GCL, anticorps LOC100302444, anticorps Gcr, anticorps Grl, anticorps Grl-1, anticorps Grl1, anticorps GRL, anticorps GCCR, anticorps GCR, anticorps NO, anticorps GR-A, anticorps nr3c1, anticorps nuclear receptor subfamily 3 group C member 1, anticorps nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), anticorps nuclear receptor subfamily 3, group C, member 1, anticorps glucocorticoid receptor, anticorps NR3C1, anticorps nr3c1, anticorps LOC100302444, anticorps Nr3c1

Sujet: NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance.
Alias Symbols: GCCR, GCR, GR, GRL
Protein Interaction Partner: TTC5, HSP90AA1, TXN2, UBC, TXN, FKBP5, DCAF6, RABEP2, BRCC3, LARP7, GAPVD1, CD2AP, SF3A1, HNRNPR, TRIM28, HDAC1, MTA2, CCDC6, CENPB, TMF1, PPARG, STUB1, BAG1, RPS6KA5, NCOA1, POLR1D, NCOA2, SRA1, PRKDC, RAD54L2, MAGEA11, PPP5C, PPID, GNB2, GNB1, FKBP4, GN
Protein Size: 777

Poids moléculaire: 86 kDa

ID gène: 2908

NCBI Accession: NM_001018076, NP_001018086

UniProt: P04150

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process