NCOA2 anticorps (Middle Region)

N° du produit ABIN2777581

Détail du produit anti-NCOA2 anticorps

Antigène: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Lapin, Chien, Boeuf (Vache), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOA2 est non-conjugé

Application: Western Blotting (WB)

Séquence: LLPKSIVNGG SWSGEPPRRN SHTFNCRMLV KPLPDSEEEG HDNQEAHQKY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NCOA2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NCOA2

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NCOA2

Antigène: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Autre désignation: NCOA2 (NCOA2 Produits)

Synonymes: anticorps GRIP1, anticorps KAT13C, anticorps NCoA-2, anticorps SRC2, anticorps TIF2, anticorps bHLHe75, anticorps 9530095N19, anticorps D1Ertd433e, anticorps GRIP-1, anticorps Grip1, anticorps SRC-2, anticorps TIF-2, anticorps tif2, anticorps wu:fc41a10, anticorps wu:fe26a11, anticorps Tif2, anticorps NCOA2, anticorps XTIF2, anticorps bhlhe75, anticorps grip1, anticorps kat13c, anticorps src2, anticorps ncoa2-A, anticorps nuclear receptor coactivator 2, anticorps nuclear receptor coactivator 2 S homeolog, anticorps NCOA2, anticorps Ncoa2, anticorps ncoa2, anticorps LOC100089041, anticorps ncoa2.S

Sujet: The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]
Alias Symbols: SRC2, TIF2, GRIP1, KAT13C, NCoA-2, bHLHe75
Protein Size: 370

Poids moléculaire: 40 kDa

ID gène: 10499

NCBI Accession: NM_006540, NP_006531

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling