CIITA anticorps (Middle Region)
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- Antigène Voir toutes CIITA Anticorps
- CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
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Épitope
- Middle Region
- Reactivité
- Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Cobaye, Cheval, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CIITA est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- YNKFTAAGAQ QLAASLRRCP HVETLAMWTP TIPFSVQEHL QQQDSRISLR
- Homologie
- Cow: 79%, Dog: 86%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against CIITA. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human CIITA
- Top Product
- Discover our top product CIITA Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1130 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
- Autre désignation
- CIITA (CIITA Produits)
- Synonymes
- anticorps CIITA, anticorps C2ta, anticorps EG669998, anticorps Gm9475, anticorps C2TA, anticorps CIITAIV, anticorps MHC2TA, anticorps NLRA, anticorps Mhc2ta, anticorps class II, major histocompatibility complex, transactivator, anticorps class II major histocompatibility complex transactivator, anticorps MHC class II transactivator, anticorps class II transactivator, anticorps CIITA, anticorps LOC710761, anticorps ciita, anticorps LOC100443575, anticorps Ciita, anticorps LOC100736732
- Sujet
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CIITA is a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: C2TA, CIITA IV, MHC2TA, NLRA, CIITAIV
Protein Interaction Partner: PSMC5, CUL3, TAF9, GTF2B, PSMC3, PSMC2, SIN3B, HDAC2, GSK3B, HDAC5, HDAC4, SMARCA4, RFX5, HDAC1, ZXDC, TAF6, KAT2B, RFXANK, NCOA1, XPO1, PRKACA, NFYB, MAPK3, MAPK1, CDK1, HIST4H4, POLR2A, ACTB,
Protein Size: 1130 - Poids moléculaire
- 123 kDa
- ID gène
- 4261
- NCBI Accession
- NM_000246, NP_000237
- UniProt
- P33076
- Pathways
- Cancer Immune Checkpoints
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