PCSK5 anticorps (Middle Region)

N° du produit ABIN2781306

Détail du produit anti-PCSK5 anticorps

Antigène: PCSK5 (Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCSK5 est non-conjugé

Application: Western Blotting (WB)

Séquence: CAGAGADGCI NCTEGYFMED GRCVQSCSIS YYFDHSSENG YKSCKKCDIS

Homologie: Cow: 100%, Dog: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against PCSK5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PCSK5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 913 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PCSK5 (ABIN2781306)

Szumska, Pieles, Essalmani, Bilski, Mesnard, Kaur, Franklyn, El Omari, Jefferis, Bentham, Taylor, Schneider, Arnold, Johnson, Tymowska-Lalanne, Stammers, Clarke, Neubauer, Morris, Brown, Shaw-Smith, Cama, Capra, Ragoussis, Constam, Seidah, Prat, Bhattacha: "VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5." dans: Genes & development, Vol. 22, Issue 11, pp. 1465-77, (2008) (PubMed).

Détails sur PCSK5

Antigène: PCSK5 (Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5))

Autre désignation: PCSK5 (PCSK5 Produits)

Synonymes: anticorps PC5, anticorps PC6, anticorps PC6A, anticorps SPC6, anticorps subtilase, anticorps PC5/6A, anticorps PC5A, anticorps b2b1549Clo, anticorps b2b585Clo, anticorps Pc5, anticorps fur2, anticorps spc6, anticorps spc6A, anticorps MGC98915, anticorps PCSK5, anticorps pc6, anticorps spc6a, anticorps pcsk5, anticorps zgc:165659, anticorps proprotein convertase subtilisin/kexin type 5, anticorps proprotein convertase subtilisin/kexin type 5 S homeolog, anticorps proprotein convertase subtilisin/kexin type 5b, anticorps PCSK5, anticorps Pcsk5, anticorps pcsk5.S, anticorps LOC528098, anticorps pcsk5, anticorps pcsk5b

Sujet: PCSK5 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. PCSK5 mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PC5, PC6, PC6A, SPC6
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-8, KRTAP10-7, LCE3C, KRTAP4-12, NUFIP2, GLRX3, STK16, MEOX2, KRTAP5-9, env, Hoxa1, ATN1, UBC, CACNA1A, APPBP2, AMH, REN, PTPRM, PMCH, ITGA6,
Protein Size: 913

Poids moléculaire: 89 kDa

ID gène: 5125

NCBI Accession: NM_006200, NP_006191

UniProt: Q92824

Pathways: Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones