POLK anticorps (N-Term)
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- Antigène Voir toutes POLK Anticorps
- POLK (Polymerase (DNA Directed) kappa (POLK))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Cheval, Porc, Boeuf (Vache), Chien, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp POLK est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- KINKIIMEAT KGSRFYGNEL KKEKQVNQRI ENMMQQKAQI TSQQLRKAQL
- Homologie
- Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against POLK. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human POLK
- Top Product
- Discover our top product POLK Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 870 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- POLK (Polymerase (DNA Directed) kappa (POLK))
- Autre désignation
- POLK (POLK Produits)
- Synonymes
- anticorps DINB1, anticorps DINP, anticorps POLQ, anticorps Dinb1, anticorps POLK, anticorps si:ch211-254o18.3, anticorps DNA polymerase kappa, anticorps polymerase (DNA directed) kappa, anticorps polymerase (DNA directed), kappa, anticorps polymerase (DNA directed) kappa L homeolog, anticorps POLK, anticorps Polk, anticorps polk, anticorps Tb11.01.0080, anticorps Tb11.01.0010, anticorps Tb11.01.0020, anticorps Tb11.01.0030, anticorps Tb11.01.0040, anticorps Tb11.01.0050, anticorps Tb11.12.0001, anticorps Tb11.12.0002, anticorps Tb11.12.0003, anticorps polk.L, anticorps polk-1
- Sujet
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POLK belongs to the DNA polymerase type-Y family. It contains 2 Rad18-type zinc fingers and 1 umuC domain. POLK is a DNA polymerase specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. It lacks 3'-5' proofreading exonuclease activity. POLK forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Alias Symbols: DINB1, DINP, POLQ
Protein Interaction Partner: XPO7, MSH2, MCM6, MCM4, MSH6, TRAIP, UBC, REV1, Shprh, RAD18, PCNA, XRCC1, RPA1, POLD1,
Protein Size: 870 - Poids moléculaire
- 99 kDa
- ID gène
- 51426
- NCBI Accession
- NM_016218, NP_057302
- UniProt
- Q9UBT6
- Pathways
- Réparation de l'ADN
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