DFFB anticorps (Middle Region)
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- Antigène Voir toutes DFFB Anticorps
- DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
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Épitope
- Middle Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DFFB est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- EYFYGLLFTS ENLKLVHIVC HKKTTHKLNC DPSRIYKPQT RLKRKQPVRK
- Homologie
- Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against DFFB. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human DFFB
- Top Product
- Discover our top product DFFB Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 338 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
- Autre désignation
- DFFB (DFFB Produits)
- Synonymes
- anticorps CAD, anticorps CPAN, anticorps DFF-40, anticorps DFF2, anticorps DFF40, anticorps LOC100223514, anticorps 40kDa, anticorps 5730477D02Rik, anticorps Didff, anticorps Cad, anticorps carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, anticorps DNA fragmentation factor subunit beta, anticorps DNA fragmentation factor, beta polypeptide (caspase-activated DNase), anticorps DNA fragmentation factor, beta subunit, anticorps CAD, anticorps DFFB, anticorps dffb, anticorps LOC100223514, anticorps Dffb
- Sujet
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DFFB is a nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. DFFB degrades naked DNA and induces apoptotic morphology.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CAD, CPAN, DFF-40, DFF2, DFF40
Protein Interaction Partner: DFFA, UBC, NUBP1, MARCKS, APP, CAND1, COPS5, CUL1, CUL2, CUL5, NEDD8, CIDEB, DFFB, TOP2A,
Protein Size: 338 - Poids moléculaire
- 39 kDa
- ID gène
- 1677
- NCBI Accession
- NM_004402, NP_004393
- UniProt
- O76075
- Pathways
- Apoptose, Caspase Cascade in Apoptosis
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