IL4 Receptor anticorps (C-Term)

N° du produit ABIN2788560

Détail du produit anti-IL4 Receptor anticorps

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL4 Receptor est non-conjugé

Application: Western Blotting (WB)

Séquence: GLDREPPRSP QSSHLPSSSP EHLGLEPGEK VEDMPKPPLP QEQATDPLVD

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against IL4R. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IL4R

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur IL4 Receptor

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Autre désignation: IL4R (IL4R Produits)

Synonymes: anticorps IL4R, anticorps il-4ra, anticorps zgc:113063, anticorps CD124, anticorps IL-4RA, anticorps IL4RA, anticorps Il4ra, anticorps IL4, anticorps Il4r, anticorps interleukin 4 receptor, anticorps interleukin 4 receptor, tandem duplicate 1, anticorps interleukin 4 receptor, alpha, anticorps IL4R, anticorps il4r.1, anticorps Il4r, anticorps Il4ra

Sujet: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Protein Interaction Partner: UBC, JAK3, CD40, STAT6, JAK2, JAK1, IL2RG, SOCS5, KAT5, HGS, ARIH2, INPP5D, DOK2, IRS2, SHC1, IL13RA1, NCF1, FES, PRKCZ, GNB2L1, PTPN6, PTPN11, IL4, IL13, IRS1,
Protein Size: 825

Poids moléculaire: 87 kDa

ID gène: 3566

UniProt: P24394

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process