HLA-DPB1 anticorps (Middle Region)
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- Antigène Voir toutes HLA-DPB1 Anticorps
- HLA-DPB1 (Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1))
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Épitope
- Middle Region
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Reactivité
- Humain, Chien, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HLA-DPB1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- KRAVPDRMCR HNYELGGPMT LQRRVQPRVN VSPSKKGPLQ HHNLLVCHVT
- Homologie
- Dog: 86%, Human: 100%, Rabbit: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against HLA-DPB1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product HLA-DPB1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 258 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- HLA-DPB1 (Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1))
- Autre désignation
- HLA-DPB1 (HLA-DPB1 Produits)
- Synonymes
- anticorps PATR-DPB1, anticorps B-LB, anticorps B-LB2, anticorps B-LB21, anticorps BLB1, anticorps GSP-BLB1, anticorps DPB1, anticorps HLA-DP, anticorps HLA-DP1B, anticorps HLA-DPB, anticorps major histocompatibility complex, class II, DP beta 1, anticorps Major histocompatibility complex class II beta chain BLB1, anticorps PATR-DPB1, anticorps BLB1, anticorps HLA-DPB1
- Sujet
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HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Alias Symbols: DPB1, HLA-DP1B
Protein Interaction Partner: LZTS2, TRIP6, LGR4, COPB1, RTN4, ROBO2, HLA-DPA1, CD74,
Protein Size: 258 - Poids moléculaire
- 26 kDa
- ID gène
- 3115
- NCBI Accession
- NM_002121, NP_002112
- UniProt
- P04440
- Pathways
- TCR Signaling, Cancer Immune Checkpoints
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