NFKBIA anticorps (N-Term)

N° du produit ABIN2792665

Détail du produit anti-NFKBIA anticorps

Antigène: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Épitope: N-Term

Reactivité: Humain, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFKBIA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ

Réactivité croisée: Humain, Porc

Homologie: Human: 100%, Pig: 76%

Attributs du produit: This is a rabbit polyclonal antibody against NFKBIA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NFKBIA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Antigen size: 317 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NFKBIA

Antigène: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Autre désignation: NFKBIA / IKBA (NFKBIA Produits)

Synonymes: anticorps IKBA, anticorps MAD-3, anticorps NFKBI, anticorps AI462015, anticorps Nfkbi, anticorps RL/IF-1, anticorps ECI-6/IKBA, anticorps NFKBIA, anticorps ikbaB, anticorps wu:fb81f08, anticorps zgc:56666, anticorps zgc:77616, anticorps ikbaA, anticorps wu:fj16a07, anticorps zgc:85769, anticorps NFKB inhibitor alpha, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha, anticorps nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b, anticorps nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a, anticorps NFKBIA, anticorps Nfkbia, anticorps nfkbiab, anticorps nfkbiaa

Sujet: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
Alias Symbols: IKBA, MAD-3, NFKBI
Protein Interaction Partner: BTRC, NEDD9, IKBKB, CHUK, UBC, MTOR, IKBKG, SKP1, FBXW11, UBE2D3, RELA, NPLOC4, VCP, UFD1L, NFKB1, TNF, SUMO1, UBE2D1, COPS3, GPS1, SUMO3, Csnk2b, PRKCA, ST7, STAT1, REL, POLR2C, CD7, ARRB2, ARRB1, SUMO2, PSMA1, ZNF212, IKZF4, ATF4, TBK1, IKBKE, DNAJA3, S
Protein Size: 317

Poids moléculaire: 36 kDa

ID gène: 4792

NCBI Accession: NM_020529, NP_065390

UniProt: P25963

Pathways: Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling