DR3/LARD anticorps (Center)
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- Antigène Voir toutes DR3/LARD (TNFRSF25) Anticorps
- DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))
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Épitope
- Center
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DR3/LARD est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Attributs du produit
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Rabbit Polyclonal antibody to DR3 (tumor necrosis factor receptor superfamily, member 25)
DR3 antibody - Purification
- Purified by antigen-affinity chromatography.
- Immunogène
- Recombinant protein encompassing a sequence within the center region of human DR3. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product TNFRSF25 Anticorps primaire
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- Indications d'application
- Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
- Commentaires
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Positive Control: Raji , K562
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- Agent conservateur
- Thimerosal (Merthiolate)
- Précaution d'utilisation
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Antigène
- DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))
- Autre désignation
- DR3 (TNFRSF25 Produits)
- Synonymes
- anticorps APO-3, anticorps DDR3, anticorps DR3, anticorps LARD, anticorps TNFRSF12, anticorps TR3, anticorps TRAMP, anticorps WSL-1, anticorps WSL-LR, anticorps Tnfrsf12, anticorps Wsl, anticorps TNFRSF25, anticorps TNF receptor superfamily member 25, anticorps tumor necrosis factor receptor superfamily, member 25, anticorps TNFRSF25, anticorps Tnfrsf25
- Sujet
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Cellular Localization: Isoform 1: Cell membrane, Single-pass type I membrane protein , Isoform 2: Cell membrane, Single-pass type I membrane protein , Isoform 9: Cell membrane, Single-pass type I membrane protein , Isoform 11: Cell membrane, Single-pass type I membrane protein - Poids moléculaire
- 45 kDa
- ID gène
- 8718
- Pathways
- Apoptose
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