STAT6 anticorps (pTyr641)

N° du produit ABIN3020502

Détail du produit anti-STAT6 anticorps

Antigène: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Épitope: pTyr641

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAT6 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Attributs du produit: Phosphorylated Antibodies

Immunogène: A phospho specific peptide corresponding to residues surrounding Y641 of human STAT6

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-STAT6 (ABIN3020502)

Shen, Li, You, Wu, Wu, Zhao, Zhu, Guo, Li, Li, Ma, Yang, Chen: "Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 99, pp. 60-69, (2017) (PubMed).

Détails sur STAT6

Antigène: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Autre désignation: STAT6 (STAT6 Produits)

Synonymes: anticorps D12S1644, anticorps IL-4-STAT, anticorps STAT6B, anticorps STAT6C, anticorps signal transducer and activator of transcription 6, anticorps signal transducer and activator of transcription 6-like, anticorps STAT6, anticorps Stat6, anticorps LOC100859543

Sujet: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.,D12S1644,IL-4-STAT,STAT6B,STAT6C,STAT6,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,Protein phosphorylation,STAT6

Poids moléculaire: 74 kDa/81 kDa/94 kDa

ID gène: 6778

UniProt: P42226

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response