TNFRSF1B anticorps (Middle Region)

N° du produit ABIN3029368

Détail du produit anti-TNFRSF1B anticorps

Antigène: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNFRSF1B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human TNF Receptor 2 (DQVETQACTREQNRICTCR) was used as the immunogen for this TNFR2 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the TNFR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the TNFR2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur TNFRSF1B

Antigène: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Autre désignation: TNFR2 (TNFRSF1B Produits)

Synonymes: anticorps CD120b, anticorps TBPII, anticorps TNF-R-II, anticorps TNF-R75, anticorps TNFBR, anticorps TNFR1B, anticorps TNFR2, anticorps TNFR80, anticorps p75, anticorps p75TNFR, anticorps TNF-RII/TNFRSF1B, anticorps TNFR-II, anticorps TNFRSF1B, anticorps TNF-R2, anticorps TNF-alphaR2, anticorps TNFRII, anticorps TNFalpha-R2, anticorps Tnfr-1, anticorps Tnfr2, anticorps rank, anticorps zgc:163064, anticorps TNF receptor superfamily member 1B, anticorps tumor necrosis factor receptor superfamily, member 1b, anticorps tumor necrosis factor receptor superfamily, member 1B, anticorps TNFRSF1B, anticorps Tnfrsf1b, anticorps tnfrsf1b

Sujet: Tumor necrosis factor receptor 2 is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55- kDa protein, and TNFR2, a 70- kDa protein, have been mapped to human chromosomes 12(12pter-cen) and 1(1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.

UniProt: P20333

Pathways: Signalisation NF-kappaB, Apoptose, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway