XRCC1 anticorps (N-Term)

N° du produit ABIN3029646

Détail du produit anti-XRCC1 anticorps

Antigène: XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XRCC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of human XRCC1 (QDSTHCAENLLKADTYRKWR) was used as the immunogen for this XRCC1 antibody (100% mouse homology).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the XRCC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the XRCC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur XRCC1

Antigène: XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))

Autre désignation: XRCC1 (XRCC1 Produits)

Synonymes: anticorps xrcc1, anticorps MGC80909, anticorps XRCC1, anticorps rcc, anticorps RCC, anticorps Xrcc-1, anticorps X-ray repair complementing defective repair in Chinese hamster cells 1, anticorps X-ray repair cross complementing 1, anticorps xrcc1, anticorps XRCC1, anticorps Xrcc1

Sujet: X-ray repair, complementing defective, in chinese hamster 1 is a DNA repair protein which complexes with DNA ligase III. The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. The XRCC1 gene is mapped to 19q13.31. The protein interacts with DNA ligase III, polymerase beta and poly(ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. XRCC1 is phosphorylated in vivo and in vitro by CK2, and CK2 phosphorylation of ser518, thr519, and thr523 largely determines aprataxin binding to XRCC1 through its FHA domain.

UniProt: P18887

Pathways: Réparation de l'ADN