KHDRBS1 anticorps (N-Term)

N° du produit ABIN3031544

Détail du produit anti-KHDRBS1 anticorps

Antigène: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KHDRBS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of human SQSTM1 (KDDIFRIYIKEKKECRRDHR) was used as the immunogen for this p62 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the p62 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the p62 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur KHDRBS1

Antigène: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Autre désignation: p62 (KHDRBS1 Produits)

Synonymes: anticorps Sam68, anticorps p62, anticorps p68, anticorps fj90g10, anticorps khdrbs1, anticorps wu:fa18g12, anticorps wu:fa56c01, anticorps wu:fc91b01, anticorps wu:fj90g10, anticorps zgc:113899, anticorps KHDRBS1, anticorps P62, anticorps khdrbs1l, anticorps sb:cb97, anticorps wu:fb07d11, anticorps wu:fi43c05, anticorps zgc:85948, anticorps KH RNA binding domain containing, signal transduction associated 1, anticorps KH domain containing, RNA binding, signal transduction associated 1a, anticorps KH domain containing, RNA binding, signal transduction associated 1, anticorps KH domain containing, RNA binding, signal transduction associated 1 S homeolog, anticorps KH domain containing, RNA binding, signal transduction associated 1b, anticorps KHDRBS1, anticorps khdrbs1a, anticorps khdrbs1, anticorps Khdrbs1, anticorps khdrbs1.S, anticorps khdrbs1b

Sujet: Sequestosome-1, also known as Ubiquitin-Binding Protein p62, is a protein that in humans is encoded by the SQSTM1 gene. The Src homology type 2(SH2) domain is a highly conserved motif of about 100 amino acids which mediates protein-protein interactions by binding to phosphotyrosine.p56-lck, a T-cell-specific src family tyrosine kinase with an SH2 domain, is involved in T-cell signal transduction. The International Radiation Hybrid Mapping Consortium mapped the p62 gene to chromosome 5q35. Park et al.(1995) found that the p56-lck SH2 domain binds p62 at the ser59 only when that serine is phosphorylated. Joung et al.(1996) expressed epitope-tagged p62 in Hela cells and showed that the expressed protein bound to the lck SH2 domain and that this binding was dependent on the N-terminal 50 amino acids of p62 but not on the tyrosine residue in this region.

UniProt: Q13501

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy