KHDRBS1 anticorps (C-Term)

N° du produit ABIN6262791

Détail du produit anti-KHDRBS1 anticorps

Antigène: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KHDRBS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: KHDRBS1 Antibody detects endogenous levels of total KHDRBS1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human KHDRBS1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur KHDRBS1

Antigène: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Autre désignation: KHDRBS1 (KHDRBS1 Produits)

Synonymes: anticorps Sam68, anticorps p62, anticorps p68, anticorps fj90g10, anticorps khdrbs1, anticorps wu:fa18g12, anticorps wu:fa56c01, anticorps wu:fc91b01, anticorps wu:fj90g10, anticorps zgc:113899, anticorps KHDRBS1, anticorps P62, anticorps khdrbs1l, anticorps sb:cb97, anticorps wu:fb07d11, anticorps wu:fi43c05, anticorps zgc:85948, anticorps KH RNA binding domain containing, signal transduction associated 1, anticorps KH domain containing, RNA binding, signal transduction associated 1a, anticorps KH domain containing, RNA binding, signal transduction associated 1, anticorps KH domain containing, RNA binding, signal transduction associated 1 S homeolog, anticorps KH domain containing, RNA binding, signal transduction associated 1b, anticorps KHDRBS1, anticorps khdrbs1a, anticorps khdrbs1, anticorps Khdrbs1, anticorps khdrbs1.S, anticorps khdrbs1b

Sujet:

Description: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity).

Gene: KHDRBS1

Poids moléculaire: 48 kDa

ID gène: 10657

UniProt: Q07666

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy