SCN5A anticorps (Internal Region)

N° du produit ABIN303416

Détail du produit anti-SCN5A anticorps

Antigène: SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))

Épitope: Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SCN5A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody recognises SCN5A.

Purification: Immunoaffinity Chromatography.

Immunogène: Amino Acids (C)ETDDQSPEKIN from an internal region of human SCN5A.

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections (5-10 μg/mL). ELISA (1/32000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris buffered saline containing 0.5 % BSA and 0.02 % sodium azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid cycles of freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at-20 °C. Dilute only prior to immediate use.

Détails sur SCN5A

Antigène: SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))

Autre désignation: SCN5A (SCN5A Produits)

Synonymes: anticorps Nav1.5, anticorps Nav1.5c, anticorps SkM1, anticorps SkM2, anticorps mH1, anticorps CDCD2, anticorps CMD1E, anticorps CMPD2, anticorps HB1, anticorps HB2, anticorps HBBD, anticorps HH1, anticorps ICCD, anticorps IVF, anticorps LQT3, anticorps PFHB1, anticorps SSS1, anticorps VF1, anticorps SCAL, anticorps sodium voltage-gated channel alpha subunit 5, anticorps sodium channel, voltage-gated, type V, alpha, anticorps SCN5A, anticorps Scn5a

Sujet: Scn5a encodes the alpha subunit of the type V voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type V channel has been shown to be tetrodotoxin-resistant. Scn5a null mice experience intrauterine lethality. Mutations in the SCN5A gene are responsible for several heart conditions, including the chromosome 3-linked form of long LQT and Brugada syndrome.Synonyms: CDCD2, HB1, HB2, HBBD, HH1, LQT3, Nav1.5, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type 5 subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5

ID gène: 6331

NCBI Accession: NP_000326

UniProt: Q14524