c-MET anticorps (AA 208-407)

N° du produit ABIN3042360

Détail du produit anti-c-MET anticorps

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Épitope: AA 208-407

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-MET est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Hepatocyte growth factor receptor(MET) detection. Tested with WB in Human,Rat.

Réactivité croisée (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Hepatocyte growth factor receptor(MET) detection. Tested with WB in Human,Rat.
Gene Name: MET proto-oncogene, receptor tyrosine kinase
Protein Name: Hepatocyte growth factor receptor

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Met recombinant protein (Position: D208-S407). Human Met shares 90% and 91% amino acid (aa) sequences identity with mouse and rat Met, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, The detection limit for Met is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-c-MET (ABIN3042360)

Chen, Ding, Gao, Sun, Zhang, Du, Qiu, Wang, Zheng, Sun, Ni, Feng, Zhu: "A human anti-c-Met Fab fragment conjugated with doxorubicin as targeted chemotherapy for hepatocellular carcinoma." dans: PLoS ONE, Vol. 8, Issue 5, pp. e63093, (2013) (PubMed).

Bin, Ma, Xu, Shi: "Embryonic hepatocyte transplantation for hepatic cirrhosis: efficacy and mechanism of action." dans: World journal of gastroenterology, Vol. 18, Issue 4, pp. 309-22, (2012) (PubMed).

Chen, Wang, Guo, Yu, Burnstock, He, Xiang, Zheng: "Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair." dans: Journal of anatomy, Vol. 218, Issue 6, pp. 643-51, (2011) (PubMed).

Détails sur c-MET

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Autre désignation: MET (MET Produits)

Synonymes: anticorps AUTS9, anticorps HGFR, anticorps RCCP2, anticorps c-Met, anticorps AI838057, anticorps HGF, anticorps Par4, anticorps Hgfr, anticorps c-met, anticorps MET, anticorps C-MET, anticorps met, anticorps met-A, anticorps MET proto-oncogene, receptor tyrosine kinase, anticorps met proto-oncogene, anticorps MET proto-oncogene, receptor tyrosine kinase L homeolog, anticorps MET, anticorps Met, anticorps met.L

Sujet: C-Met, also called MET and hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. It is mapped to 7q31.2. The protein possesses tyrosine kinase activity. MET is a membrane receptor that is essential for embryonic development and wound healing. It induces several biological responses that collectively give rise to a program known as invasive growth. MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body.

Synonyms: AUTS9 antibody|c met antibody|c met antibody|cmet antibody|cmet antibody|D249 antibody|Hepatocyte growth factor receptor antibody|Hepatocyte growth factor receptor Precursor antibody|Hepatocyte growth factor receptor Precursor antibody|HGF antibody|HGF receptor antibody|HGF receptor antibody|HGF SF receptor antibody|HGF SF receptor antibody|HGF/SF receptor antibody|HGFR antibody|MET antibody|Met proto oncogene tyrosine kinase antibody|Met proto oncogene tyrosine kinase antibody|MET proto oncogene, receptor tyrosine kinase antibody|Met proto-oncogene (hepatocyte growth factor receptor) antibody|Met proto-oncogene antibody|Met protooncogene antibody|MET_HUMAN antibody|Oncogene MET antibody|Oncogene MET antibody|Par4 antibody|Proto-oncogene c-Met antibody|RCCP2 antibody|Renal cell carcinoma papillary 2 gene antibody|Renal cell carcinoma papillary 2 gene antibody|Scatter factor receptor antibody|SF receptor antibody|Tyrosine-protein kinase Met antibody

ID gène: 4233

UniProt: P08581

Pathways: Signalisation RTK, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor