RALB anticorps (C-Term)

N° du produit ABIN3043919

Détail du produit anti-RALB anticorps

Antigène: RALB (Ralb) (V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb))

Épitope: AA 166-203, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RALB est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Ras-related protein Ral-B(RALB) detection. Tested with WB in Human,Mouse,Rat.

Séquence: DKVFFDLMRE IRTKKMSENK DKNGKKSSKN KKSFKERC

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Ras-related protein Ral-B(RALB) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: v-ral simian leukemia viral oncogene homolog B
Protein Name: Ras-related protein Ral-B

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human RALB (166-203aa DKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERC), different from the related mouse sequence by three amino acids, and from the related rat sequence by four amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur RALB

Antigène: RALB (Ralb) (V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb))

Autre désignation: RALB (Ralb Produits)

Synonymes: anticorps dRalb, anticorps 5730472O18Rik, anticorps Ral B, anticorps ralb, anticorps xralb, anticorps zgc:100801, anticorps KRAS2, anticorps k-ras, anticorps RAS like proto-oncogene B, anticorps v-ral simian leukemia viral oncogene B, anticorps v-ral simian leukemia viral oncogene homolog B L homeolog, anticorps v-ral simian leukemia viral oncogene homolog Ba (ras related), anticorps v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein), anticorps RALB, anticorps Ralb, anticorps ralb.L, anticorps ralba, anticorps ralb

Sujet: Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two isoforms of the Ral protein, the other being RalA, and part of the Ras GTPase family. As a Ras GTPase, RalB functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP. RalB can be activated by RalGEFs and, in turn, activate effectors in signal transduction pathways leading to biological outcomes. Additionally, Ral proteins have been associated with the progression of several cancers, including bladder cancer and prostate cancer. While the above functions appear to be shared between the two Ral isoforms, their differential subcellular localizations result in their differing involvement in certain biological processes. In particular, RalB is more involved in apoptosis and cell motility. Moreover, RalB specifically interacts with Exo84 to assemble the beclin-1-VPS34 autophagy initiation complex, and with Sec5 to activate the innate immune response via the Tank-binding kinase 1 (TBK1).

Synonyms: 5730472O18Rik antibody|dRalb antibody|GTP binding protein antibody|Ralb antibody|RALB_HUMAN antibody|RAS like protein B antibody|Ras related GTP binding protein B antibody|Ras-related protein Ral-B antibody|v ral simian leukemia viral oncogene homolog B (ras related GTP binding protein) antibody|v ral simian leukemia viral oncogene homolog B (ras related) antibody|V ral simian leukemia viral oncogene homolog B antibody

ID gène: 5899

UniProt: P11234

Pathways: Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events