TRIM29 anticorps (Internal Region)
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- Antigène Voir toutes TRIM29 Anticorps
- TRIM29 (Tripartite Motif Containing 29 (TRIM29))
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Épitope
- Internal Region
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Reactivité
- Humain, Boeuf (Vache), Cheval, Macaque, Chimpanzé
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TRIM29 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- Anti-ATDC antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with over-expressed, acetylated and non-acetylated (at K116) ATDC protein. A BLAST analysis was used to suggest cross-reactivity with ATDC from human, horse, bovine, chimpanzee and macaque based on a 100% homology with the immunizing sequence. Partial reactivity is expected against rat and mouse ATDC based on 92% homology with the immunizing sequence. Cross-reactivity with ATDC from other sources has not been determined.
- Réactivité croisée
- Cheval, Mouton, Chimpanzé, Macaque
- Attributs du produit
- Ataxia-telangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.
- Immunogène
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Anti-ATDC affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal portion of human ATDC protein around lysine 116.
Immunogen Type: Peptide - Isotype
- IgG
- Top Product
- Discover our top product TRIM29 Anticorps primaire
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- Indications d'application
- Anti-ATDC affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity and detection of ATDC should be optimized by the end user. Expect a band approximately ~66 kDa in size corresponding to ATDC by western blotting in the appropriate cell lysate or extract.
- Commentaires
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Gene Name: TRIM29
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
- Date de péremption
- 3 months
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- Antigène
- TRIM29 (Tripartite Motif Containing 29 (TRIM29))
- Autre désignation
- ATDC (TRIM29 Produits)
- Synonymes
- anticorps ATDC, anticorps 1110047J21Rik, anticorps 2810431N19Rik, anticorps 4732461M22Rik, anticorps AI119726, anticorps MGC53484, anticorps TRIM29, anticorps atdc, anticorps tripartite motif containing 29, anticorps tripartite motif-containing 29, anticorps tripartite motif containing 29 L homeolog, anticorps TRIM29, anticorps Trim29, anticorps trim29.L, anticorps trim29
- Sujet
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Ataxia-telangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.
Synonyms: Ataxia-telangiectasia group D associated protein antibody, ATDC antibody, FLJ36085 antibody, TRIM 29 antibody, Tripartite motif containing protein 29 antibody - ID gène
- 23650, 17402909
- UniProt
- Q14134
- Pathways
- Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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