TRPV6 anticorps (AA 320-370)

N° du produit ABIN351306

Détail du produit anti-TRPV6 anticorps

Antigène: TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))

Épitope: AA 320-370

Reactivité: Lapin

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp TRPV6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for TRPV6.

Immunogène: A synthetic peptide from aa region 320-370 of rabbit TRPV6 conjugated to an immunogenic carrier protein was used as the antigen.

Isotype: IgG

Information d'application

Indications d'application: A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur TRPV6

Antigène: TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))

Autre désignation: TRPV6 (TRPV6 Produits)

Synonymes: anticorps ecac, anticorps trpv5-6, anticorps TRPV6, anticorps trpv6, anticorps CaT, anticorps ECaC, anticorps ABP/ZF, anticorps CAT1, anticorps CATL, anticorps ECAC2, anticorps HSA277909, anticorps LP6728, anticorps ZFAB, anticorps CAT, anticorps CaT1, anticorps Cac, anticorps Ecac2, anticorps Otrpc3, anticorps transient receptor potential cation channel, subfamily V, member 6, anticorps transient receptor potential cation channel subfamily V member 6, anticorps trpv6, anticorps TRPV6, anticorps Trpv6

Sujet: Function: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Subunit: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5, heterotetramer.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in duodenum, proximal jejunum, cecum, and colon. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 5 ANK repeats. Also known as: Transient receptor potential cation channel subfamily V member 6, TrpV6, Epithelial calcium channel 2, ECaC2, Calcium transport protein 1, CaT1, Trpv6 transient receptor potential cation channel, subfamily V, member 6, CaT1, Ecac2, Otrpc3.

Pathways: TCR Signaling