FADD anticorps (Sepharose)
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- Antigène Voir toutes FADD Anticorps
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FADD est conjugé à/à la Sepharose
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Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- Specificité
- Human FADD
- Attributs du produit
- Mouse Anti-Human FADD-SEPH
- Purification
- Purified
- Immunogène
- Recombinant FADD
- Clone
- 1A11
- Isotype
- IgG1
- Top Product
- Discover our top product FADD Anticorps primaire
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- Indications d'application
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- Applications: ELISA - Quality tested WB - Quality tested IP - Quality tested
- Working Dilutions: ELISA Purified (UNLB) antibody 0.5 g/mL Immunoblotting HRP conjugate 1:4,000 - 1:8,000 Immunoprecipitation SEPH conjugate 40 L
- Restrictions
- For Research Use only
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- Buffer
- 50 tests in 2.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
- Agent conservateur
- Without preservative
- Conseil sur la manipulation
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Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C
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- Antigène
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
- Autre désignation
- FADD (FADD Produits)
- Synonymes
- anticorps MORT1, anticorps Mort1/FADD, anticorps Mort1, anticorps TNFRSF6, anticorps adaptor, anticorps fadd, anticorps mort1, anticorps xfadd, anticorps Fas associated via death domain, anticorps Fas (TNFRSF6)-associated via death domain, anticorps Fas associated via death domain S homeolog, anticorps Fas (tnfrsf6)-associated via death domain, anticorps FADD, anticorps Fadd, anticorps fadd.S, anticorps fadd
- Sujet
- Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1 β -converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.
- Pathways
- Apoptose, Signalisation TLR, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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