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MDM2 anticorps (AA 141-176)
MDM2
Reactivité: Humain
WB, IF, IHC (p), FACS
Hôte: Lapin
Polyclonal
RB7981
unconjugated
Détail du produit anti-MDM2 anticorps
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Antigène
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MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Épitope
Tous les épitopes à travers MDM2 Anticorps.
AA 141-176
Reactivité
Toutes les réactivités sur MDM2 Anticorps
Humain
Hôte
Toutes les hôtes sur MDM2 Anticorps
Lapin
Clonalité
Toutes les clonalités sur MDM2 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers MDM2 Anticorps
Cet anticorp MDM2 est non-conjugé
Application
Tous les applications à travers MDM2 Anticorps.
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This MDM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-176 amino acids from human MDM2.
Clone
RB7981
Isotype
Ig Fraction
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Alternatives
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Information d'application
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Indications d'application
IF: 1:10~50. WB: 1:2000. IHC-P: 1:10~50. FC: 1:25
Restrictions
For Research Use only
Stockage
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Références pour anticorps anti-MDM2 (ABIN388067)
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Fragou, Tzimagiorgis, Karageorgopoulos, Barbetakis, Lazopoulos, Papaioannou, Haitoglou, Kouidou : "Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression. " dans: Molecular medicine reports , Vol. 15 , Issue 4 , pp. 1455-1460 , (2017 ) (PubMed ).
Lei, Velez, Kazlauskas : "Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. " dans: Molecular and cellular biology , Vol. 31 , Issue 9 , pp. 1788-99 , (2011 ) (PubMed ).
Détails sur MDM2
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Antigène
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Autre désignation
MDM2 (MDM2 Produits )
Synonymes
anticorps ACTFS, anticorps HDMX, anticorps hdm2, anticorps zgc:109834, anticorps 1700007J15Rik, anticorps AA415488, anticorps Mdm-2, anticorps MDM2 proto-oncogene, anticorps MDM2 proto-oncogene S homeolog, anticorps Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse), anticorps MDM2 oncogene, E3 ubiquitin protein ligase, anticorps transformed mouse 3T3 cell double minute 2, anticorps MDM2, anticorps mdm2.S, anticorps Mdm2, anticorps mdm2
Sujet
MDM2 is a target of the transcription factor tumor protein p53. This protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
Poids moléculaire
55233
ID gène
4193
NCBI Accession
NP_001138811 , NP_001265391 , NP_002383
UniProt
Q00987
Pathways
Signalisation p53 , Signalisation PI3K-Akt , Cycle Cellulaire , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Autophagy , Ubiquitin Proteasome Pathway
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