ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) (AA 624-654), (Center) anticorps

Détails pour le produit réf. ABIN390060, Fournisseur: Connectez-vous pour afficher
Antigène
  • ABC21
  • GBD1
  • ICP3
  • MDR2
  • MDR2/3
  • MDR3
  • PFIC-3
  • PGY3
  • zgc:172149
  • Mdr2
  • Pgy-2
  • Pgy2
  • mdr-2
  • Pgy3
  • ABCB4a
  • DEFB1
  • PGP3
  • ABCB4
  • RUNDC3B
  • ATP binding cassette subfamily B member 4
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4
  • beta-defensin 1-like
  • RUN domain-containing protein 3B
  • ABCB4
  • abcb4
  • Abcb4
  • LOC100861170
  • LOC101122517
Épitope
AA 624-654, Center
8
8
7
5
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris
40
24
9
3
3
3
2
2
2
1
1
1
Hôte
Lapin
44
8
2
1
Clonalité (Clone)
Polyclonal ()
Conjugué
Inconjugué
5
5
4
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
43
24
21
7
5
4
4
3
3
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène This ABCB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-654 AA from the Central region of human ABCB4.
Clone RB02209
Isotype Ig Fraction
Specificité This ABCB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 632~661 amino acids from the central region of human ABCB4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Antigène
Autre désignation ABCB4 (ABCB4 Antibody Extrait)
Sujet The membrane-associated protein encoded ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined, however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
Synonyms: Multidrug resistance protein 3, P-glycoprotein 3
Poids moléculaire 140682 DA
ID gène 5244
UniProt P21439
Pathways Regulation of Lipid Metabolism by PPARalpha
Indications d'application WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption 6 months
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) (AA 624-654), (Center) antibody (ABIN390060) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) (AA 624-654), (Center) antibody (ABIN390060) ABCB4-S639 (ABIN390060) western blot analysis in mouse heart tissue lysates (35 µg/la...
Western Blotting (WB) image for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) (AA 624-654), (Center) antibody (ABIN390060) All lanes : Anti-hABCB4-S639 at 1:500 dilution Lane 1: HepG2 whole cell lysate Lane 2...
Produit citée dans: Gautier, Tietge, Boverhof, Perton, Le Guern, Masson, Rensen, Havekes, Lagrost, Kuipers: "Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein." dans: Journal of lipid research, Vol. 48, Issue 1, pp. 30-40, 2006 (PubMed). Méthode utilisée: Western Blotting (WB)

Background publications Ruetz, Gros: "Phosphatidylcholine translocase: a physiological role for the mdr2 gene." dans: Cell, Vol. 77, Issue 7, pp. 1071-81, 1994 (PubMed).

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