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HIF1A anticorps (AA 400-550)
HIF1A
Reactivité: Humain, Protozoa
WB
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-HIF1A anticorps
(cache)
Antigène
Voir toutes HIF1A Anticorps
HIF1A
(Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
Épitope
Tous les épitopes à travers HIF1A Anticorps.
AA 400-550
Reactivité
Toutes les réactivités sur HIF1A Anticorps
Humain, Protozoa
Hôte
Toutes les hôtes sur HIF1A Anticorps
Lapin
Clonalité
Toutes les clonalités sur HIF1A Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers HIF1A Anticorps
Cet anticorp HIF1A est non-conjugé
Application
Tous les applications à travers HIF1A Anticorps.
Western Blotting (WB)
Réactivité croisée
Humain, Primate
Purification
affinity purified
Immunogène
Genomic sequence made to an internal portion of the human protein (within AA 400-550). [Swiss-Prot# Q16665].
Isotype
IgG
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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 341-450) antibody
HIF1A
Reactivité: Humain, Souris, Rat, Lapin
WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Hôte: Lapin
Polyclonal
unconjugated
Information d'application
(cache)
Indications d'application
Optimal working dilutions should be determined experimentally by the investigator.
Restrictions
For Research Use only
Stockage
(cache)
Format
Liquid
Stock
-20 °C
Détails sur HIF1A
(cache)
Antigène
HIF1A
(Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
Autre désignation
HIF-1 alpha (HIF1A Produits )
Synonymes
anticorps hif1a, anticorps AA959795, anticorps HIF1alpha, anticorps MOP1, anticorps bHLHe78, anticorps HIF-1A, anticorps HIF-1alpha, anticorps HIF1, anticorps HIF1-ALPHA, anticorps PASD8, anticorps HIF1-alpha, anticorps hif-1a, anticorps hypoxia inducible factor 1 alpha, anticorps hypoxia inducible factor 1, alpha subunit, anticorps hypoxia inducible factor 1 alpha subunit, anticorps HIF (Hypoxia Inducible Factor) homologa, anticorps hif-1a, anticorps Hif1a, anticorps HIF1A, anticorps hif1a, anticorps hif-1
Sujet
HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. Itis a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF hydroxylases provide insight into hypoxic cell responses, which may be used to help isolate therapeutic targets.
UniProt
Q16665
Pathways
Positive Regulation of Peptide Hormone Secretion , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Cellular Response to Molecule of Bacterial Origin , Carbohydrate Homeostasis , Transition Metal Ion Homeostasis , Tube Formation , Regulation of Carbohydrate Metabolic Process , Signaling Events mediated by VEGFR1 and VEGFR2 , VEGFR1 Specific Signals , L'effet Warburg
Vus récemment
(cache)