ATF3 anticorps (AA 113-130)

N° du produit ABIN401262

Détail du produit anti-ATF3 anticorps

Antigène: ATF3 (Activating Transcription Factor 3 (ATF3))

Épitope: AA 113-130

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody is directed against ATF3 and is useful in determining its presence in various assays including ELISA and western blotting. It recognizes over-expressed ATF3 protein found in various expression systems.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1: 5,000 to 1: 20,000. Western blot: 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Détails sur ATF3

Antigène: ATF3 (Activating Transcription Factor 3 (ATF3))

Autre désignation: ATF3 (ATF3 Produits)

Synonymes: anticorps zgc:55526, anticorps ATF3, anticorps LRG-21, anticorps LRF-1, anticorps LRFI, anticorps atf-3, anticorps activating transcription factor 3, anticorps activating transcription factor 3 L homeolog, anticorps atf3, anticorps ATF3, anticorps Atf3, anticorps atf3.L

Sujet: ATF3, or Activating Transcription Factor 3, is a member of mammalian activation TF/CREB protein family of transcription factors. ATF3 binds the cAMP response element (cre) (consensus: 5'-gtgacgt[ac][ag]-3'), a sequence present in many viral and cellular promoters. However, ATF3 represses rather than activates transcription from promoters with ATF sites stabilizing inhibitory co-factors at the promoter. Alternate splicing forms of ATF3, called ATF3 delta Zip, lack the leucine zipper domain and do not bind DNA. ATF3 delta Zip stimulates transcription, presumably by sequestering inhibitory co-factors away from the promoter. Human ATF3 is a 20575 Da protein composed of 181 amino acids.Synonyms: ATF-3, Activating transcription factor 3, Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3

ID gène: 467

NCBI Accession: NP_001025458

UniProt: P18847

Pathways: Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response