XRCC5 anticorps (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining))

Details for Product anti-XRCC5 Antibody No. ABIN4951573
Antigène
  • AI314015
  • Ku80
  • Ku86
  • Kup80
  • KARP-1
  • KARP1
  • KU80
  • KUB2
  • NFIV
  • xrcc5-a
  • XRCC5
  • X-ray repair cross complementing 5
  • X-ray repair complementing defective repair in Chinese hamster cells 5
  • X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog
  • XRCC5
  • Xrcc5
  • xrcc5.L
Reactivité
Humain, Souris, Rat (Rattus)
240
55
34
32
10
4
4
3
2
2
2
1
1
Hôte
Lapin
184
49
10
1
Clonalité
Polyclonal
Conjugué
Cet anticorp XRCC5 est non-conjugé
7
5
5
3
3
3
3
3
3
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
210
106
101
69
57
28
24
23
13
11
7
4
3
2
2
1
1
Options
Immunogène Amino acids FSEEQRFNNFLKALQEKVEIKQLNHFWE of human Ku80 were used as the immunogen for the Ku80 antibody.
Isotype IgG
Purification Antigen affinity
Plasmids, Primers & others Plasmids, Primers & others XRCC5 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Ku80 (XRCC5 Antibody Extrait)
Sujet XRCC5 (X-ray Repair, Complementing Defective, In Chinese Hamster, 5), also known as Ku80 or Ku86, is a protein that in humans, is encoded by the XRCC5 gene. The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen, a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining (NHEJ) pathway. The XRCC5 gene is mapped to 2q35. Human colon cancer cells heterozygous for Ku86 are haploinsufficient with an increase in polyploid cells, a reduction in cell proliferation, elevated p53 levels, and a slight hypersensitivity to ionizing radiation. Functional inactivation of the second Ku86 allele results in cells with a drastically reduced doubling time. The Ku86 locus is essential in human somatic tissue culture cells by experiments demonstration. A rare microsatellite polymorphism in XRCC5 is associated with cancer in patients of varying radiosensitivity.
UniProt P13010
Pathways Réparation de l'ADN
Indications d'application Optimal dilution of the Ku80 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
Restrictions For Research Use only
Buffer 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock -20 °C
Stockage commentaire After reconstitution, the Ku80 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Images (Fournisseur)
Image no. 1 for anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibody (ABIN4951573) Western blot testing of 1) rat testis, 2) rat thymus, 3) human HeLa and 4) mouse NIH3...
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