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PIK3CA anticorps
PIK3CA
Reactivité: Humain, Souris
WB, IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-PIK3CA anticorps
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Antigène
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PIK3CA
(Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
Reactivité
Toutes les réactivités sur PIK3CA Anticorps
Humain, Souris
Hôte
Toutes les hôtes sur PIK3CA Anticorps
Lapin
Clonalité
Toutes les clonalités sur PIK3CA Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers PIK3CA Anticorps
Cet anticorp PIK3CA est non-conjugé
Application
Tous les applications à travers PIK3CA Anticorps.
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificité
This antibody detects endogenous levels of PI 3-kinase p110alpha protein. (region surrounding Arg519)
Réactivité croisée (Details)
Species reactivity (tested):Human, Mouse.
Purification
Affinity chromatography
Pureté
> 95 % by SDS-PAGE
Top Product
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Alternatives
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anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (AA 961-1068) antibody
PIK3CA
Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC
Hôte: Lapin
Polyclonal
unconjugated
Information d'application
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Indications d'application
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Détails sur PIK3CA
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Antigène
PIK3CA
(Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
Autre désignation
PIK3CA (PIK3CA Produits )
Synonymes
anticorps CLOVE, anticorps CWS5, anticorps MCAP, anticorps MCM, anticorps MCMTC, anticorps PI3K, anticorps p110-alpha, anticorps C-P3K, anticorps PI3-kinase, anticorps PI3K-alpha, anticorps pi3-k, anticorps pi3k, anticorps AA414921, anticorps C530050K14, anticorps p50alpha, anticorps p55alpha, anticorps p85alpha, anticorps 6330412C24Rik, anticorps caPI3K, anticorps p110, anticorps p110alpha, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, anticorps Phosphoinositide-3-kinase, catalytic, alpha polypeptide, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, anticorps phosphoinositide-3-kinase regulatory subunit 1, anticorps PIK3CA, anticorps GL50803_14855, anticorps pik3ca, anticorps Pik3ca, anticorps Pik3r1
Sujet
Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of 85 kDa (p85) and 110 kDa (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85alpha and p85beta), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110alpha and p110beta interact with p85alpha, and p110alpha has also been shown to interact with p85beta in vitro. p110delta expression is restricted to white blood cells. It has been shown to bind p85alpha and beta, but it apparently does not phosphorylate these subunits. p110delta seems to have the capacity to autophosphorylate. p110gamma does not interact with the p85 subunits. It has been shown to be activated by alpha and beta-gamma heterotrimeric G proteins.Synonyms: 5-bisphosphate 3-kinase catalytic subunit alpha isoform, EC=2.7.1.153, PI3-kinase p110 subunit alpha, PI3K, PIK3CA, Phosphatidylinositol-4, PtdIns-3-kinase p110
Poids moléculaire
approx. 110 kDa
ID gène
5290
NCBI Accession
NP_006209
UniProt
P42336
Pathways
Signalisation PI3K-Akt , Signalisation RTK , TCR Signaling , AMPK Signaling , Interferon-gamma Pathway , Signalisation TLR , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Inositol Metabolic Process , Hepatitis C , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , VEGFR1 Specific Signals , VEGF Signaling
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