EPH Receptor A2 anticorps (AA 901-976) (Alexa Fluor 680)
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- Antigène Voir toutes EPH Receptor A2 (EPHA2) Anticorps
- EPH Receptor A2 (EPHA2)
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Épitope
- AA 901-976
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EPH Receptor A2 est conjugé à/à la Alexa Fluor 680
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Dog,Cow,Monkey
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human EphA2
- Isotype
- IgG
- Top Product
- Discover our top product EPHA2 Anticorps primaire
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- Indications d'application
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- EPH Receptor A2 (EPHA2)
- Autre désignation
- EphA2 (EPHA2 Produits)
- Synonymes
- anticorps ARCC2, anticorps CTPA, anticorps CTPP1, anticorps CTRCT6, anticorps ECK, anticorps epha2, anticorps MGC89505, anticorps AW545284, anticorps Eck, anticorps Myk2, anticorps Sek-2, anticorps Sek2, anticorps id:ibd5152, anticorps rtk6, anticorps G42, anticorps XE10, anticorps epha2-A, anticorps EPH receptor A2, anticorps Eph receptor A2, anticorps epoxide hydrolase, anticorps eph receptor A2 a, anticorps EPH receptor A2 L homeolog, anticorps EPHA2, anticorps Epha2, anticorps epha2, anticorps ephA2, anticorps epha2a, anticorps epha2.L
- Sujet
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Synonyms: ECK, CTPA, ARCC2, CTPP1, CTRCT6, Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2
Background: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
- ID gène
- 1969
- UniProt
- P29317
- Pathways
- Signalisation RTK
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