DDIT4 anticorps (N-Term)

N° du produit ABIN5516240

Détail du produit anti-DDIT4 anticorps

Antigène: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDIT4 est non-conjugé

Application: Western Blotting (WB)

Séquence: LWDRFSSSST SSSPSSLPRT PTPDRPPRSA WGSATREEGF DRSTSLESSD

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DDIT4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DDIT4

Antigène: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Autre désignation: DDIT4 (DDIT4 Produits)

Synonymes: anticorps redd1, anticorps Dig2, anticorps REDD-1, anticorps REDD1, anticorps 5830413E08Rik, anticorps AA415483, anticorps Rtp801, anticorps dig2, anticorps rtp801, anticorps sb:cb821, anticorps zgc:64114, anticorps DNA damage inducible transcript 4, anticorps DNA-damage-inducible transcript 4, anticorps DNA damage inducible transcript 4 S homeolog, anticorps ddit4, anticorps DDIT4, anticorps Ddit4, anticorps ddit4.S

Sujet: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

Alias Symbols: Dig2, REDD1, REDD-1

Protein Size: 232

ID gène: 54541

NCBI Accession: NM_019058, NP_061931

UniProt: Q9NX09

Pathways: Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process