Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This CYP2B6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6.
CYP2B6
Reactivité: Humain, Souris
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
For WB starting dilution is: 1:2000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Restrictions
For Research Use only
Format
Liquid
Concentration
0.36 mg/mL
Buffer
Supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antigène
CYP2B6
(Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))
anticorps CPB6, anticorps CYP2B, anticorps CYP2B7, anticorps CYP2B7P, anticorps CYPIIB6, anticorps EFVM, anticorps IIB1, anticorps P450, anticorps CPF3, anticorps CYP4F, anticorps LTB4H, anticorps CYP2B30, anticorps CYP2B11, anticorps CYPIIB11, anticorps 21-OH, anticorps 21OH, anticorps 21OHA, anticorps 21OHB, anticorps CYP21OH-A, anticorps Cyp21, anticorps Cyp21-ps1, anticorps Cyp21B, anticorps Cyp21a2-ps, anticorps Cyp21a2ps, anticorps Oh21-1, anticorps Oh21-2, anticorps CYP2B6, anticorps cytochrome P450 family 2 subfamily B member 6, anticorps cytochrome P450 family 4 subfamily F member 3, anticorps cytochrome P450, family 2, subfamily B, polypeptide 6, anticorps cytochrome P450 family 2 subfamily B member 6 L homeolog, anticorps cytochrome P450 2B11, anticorps cytochrome P450, family 21, subfamily a, polypeptide 1, anticorps cytochrome P450 subfamily 2B, anticorps cytochrome P450 2B11-like, anticorps CYP2B6, anticorps CYP4F3, anticorps cyp2b6.L, anticorps Cyp21a1, anticorps LOC100068603
Sujet
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described, however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.