Glucocorticoid Receptor anticorps (AA 236-262)

N° du produit ABIN5536219

Détail du produit anti-Glucocorticoid Receptor anticorps

Antigène: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Épitope: AA 236-262

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glucocorticoid Receptor est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-262 amino acids from the Central region of human NR3C1.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

For IF starting dilution is: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Glucocorticoid Receptor

Antigène: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Autre désignation: NR3C1 (NR3C1 Produits)

Synonymes: anticorps GR, anticorps gcr, anticorps grl, anticorps xGR, anticorps gccr, anticorps gr, anticorps zgc:113038, anticorps NR3C1, anticorps GCL, anticorps LOC100302444, anticorps Gcr, anticorps Grl, anticorps Grl-1, anticorps Grl1, anticorps GRL, anticorps GCCR, anticorps GCR, anticorps NO, anticorps GR-A, anticorps nr3c1, anticorps nuclear receptor subfamily 3 group C member 1, anticorps nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), anticorps nuclear receptor subfamily 3, group C, member 1, anticorps glucocorticoid receptor, anticorps NR3C1, anticorps nr3c1, anticorps LOC100302444, anticorps Nr3c1

Sujet: NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.

Poids moléculaire: 86 kDa

ID gène: 2908

UniProt: P04150

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process